Dose‐Response Association of Handgrip Strength With Alzheimer's Disease: A Longitudinal Study Involving 85,979 Adults Artículo académico uri icon

Abstracto

  • ABSTRACTObjectiveTo investigate the dose‐response relationship between handgrip strength and incidence of Alzheimer's disease (AD) in middle‐aged and older adults.DesignLongitudinal study.Patients and MethodsA longitudinal study was conducted in people over 50 years old in 27 European countries and Israel. Data were collected from waves 1, 2, 4, 5, 6, 7 and 8 of the Survey of Health, Ageing and Retirement in Europe (SHARE) between February 2004 and January 2021. Handgrip strength was measured with a hand dynamometer. AD was self‐reported based on previous diagnosis. Dose‐response associations were assessed by restricted cubic splines.ResultsA total of 85,979 (55.8% female) participants were followed for a median of 9.3 years. Over this time, 3324 (3.9%) developed AD. In the adjusted model, for participants < 65 years, those in the middle third of handgrip strength showed a lower risk of AD compared to the lower third (HR = 0.63, 95% CI: 0.47–0.84), as well as participants in the upper third (HR = 0.63, 95% CI: 0.47–0.85). The spline model determined that the minimum and optimal doses of handgrip strength for a significant reduction in the risk of AD for those aged < 65 years were 54 kg (HR = 0.99; 95% CI: 0.08–0.99) and 56 kg (HR = 0.27; 95% CI: 0.08–0.91), respectively. Among those aged ≥ 65 years, the minimum and optimal doses were 31 kg (HR = 0.69; 95% CI: 0.48–0.99) and 49 kg (HR = 0.57; 95% CI: 0.43–0.76), respectively.ConclusionHigher levels of handgrip strength showed a lower risk of developing AD, among adults aged 50 years and over. However, the dose‐response relationship is limited to specific ranges according to age group. We identified a range between 54 and 56 kg years and a range between 31 and 49 kg as suitable to prevent AD in adults aged 50–64 and ≥ 65 years, respectively. Routine assessment of hand grip strength can help healthcare professionals identify people at increased risk of AD. Strength‐based interventions could provide a practical strategy to support cognitive health and reduce the risk of dementia in clinical practice.

autores

  • Núñez‐Cortés, Rodrigo
  • Calatayud, Joaquín
  • Calonge‐Pascual, Sergio
  • Andersen, Lars Louis
  • Bláfoss, Rúni
  • Lopez Gil, Jose Francisco
  • López‐Bueno, Rubén

fecha de publicación

  • 2025

Página inicial

  • e70137

Volumen

  • 40

Cuestión

  • 8